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4-ACO-DMT Shortage Leads to New Knockoffs – Mushroom Prices Plummet!

By Rev

The entheogenic market is currently undergoing a significant transition, underscored by the contrasting production costs and efficiencies between organic mushroom extracts and synthetic alternatives like 5-AcO-DET. For example, producing a 25mg psilocybin-infused chocolate bar using organic extracts, with a mere 2% potency, incurs an approximate cost of $12.40, largely due to the considerable volume needed to achieve the desired dose. In contrast, the utilization of 5-AcO-DET, boasting a 99.5% purity, dramatically reduces the cost per bar to around $2.25, not only demonstrating the economic advantage but also highlighting the potential for enhanced consistency and dosage control. This stark disparity underscores a broader market inclination towards synthetic entheogens, propelled by their cost-effectiveness, potency, and the pursuit of standardized therapeutic outcomes, marking a pivotal moment for both producers and consumers within the psychedelic sphere.

In the ever-evolving landscape of psychedelic substances, a notable trend is the burgeoning shift towards synthetic alternatives, exemplified by compounds like 4-AcO-DET. This movement, while fostering interest, also stirs concerns among both enthusiasts and scholars. Natural psilocybin, derived from mushrooms, has been lauded for its therapeutic potential—a sentiment echoed by research in Molecular Psychiatry, which demonstrates its efficacy in psychiatric therapy. However, synthetic alkaloids are carving a niche for themselves, distinguished by their ease of access and ambiguous regulatory status. This dichotomy between synthetic psilocybin and natural mushroom extract is further highlighted by their distinct impacts on brain proteins linked to learning and memory, with mushroom extract demonstrating a more profound and enduring effect. Moreover, the unique influence on brain metabolism hints at a divergence in how each variant modulates stress and energy pathways, suggesting that natural extracts may offer supplementary benefits over their synthetic counterparts and inviting more in-depth investigation into these distinctions.

Amidst this shifting landscape, the dialogue surrounding synthetic versus organic alkaloids centers on aspects of purity, effect predictability, and therapeutic value. Synthetics, with their promise of controlled dosage and broader accessibility, nevertheless lack the intricate array of compounds present in natural sources, which might play a crucial role in the holistic therapeutic experience. This ongoing debate accentuates the imperative for further research into both synthetic and natural psychedelics to fully comprehend their potential and implications for mental health treatments.

Complicating the narrative of psychedelic research and usage is the emergent concern over unregulated head shops. These entities, often navigating through legal gray areas, have become key distributors of novel substances like 4-AcO-DET, exploiting the compound’s elusive status to circumvent established regulatory frameworks. This scenario not only hinders efforts to safeguard the quality and safety of psychedelic substances but also rings alarm bells over the ease of access to these powerful compounds, especially for minors. The absence of rigorous oversight and standardized testing protocols opens the door to the potential misuse of psychedelics, underscoring the pressing need for comprehensive policies that tackle the sale and distribution of novel psychoactive substances while prioritizing public health and safety.

Engaging with the black market for entheogens, encompassing both organic and synthetic psychedelics, introduces formidable risks that extend beyond mere legal implications. The recent debacle involving the Incognito darknet market, as detailed by Krebs on Security, starkly illustrates the inherent perils. Following an “exit scam” by its administrators, which saw them absconding with millions in cryptocurrency, they proceeded to mass-extort users, threatening to disclose sensitive transaction and chat logs unless a ransom was paid. This alarming scheme puts countless users in jeopardy, exposing them to potential legal repercussions, privacy violations, and personal harm. Such incidents vividly showcase the hazardous realities of navigating the black market, emphasizing the need for caution and highlighting the darker facets of accessing entheogens outside sanctioned and regulated channels. To gain a more comprehensive insight into this incident, consulting the article on Krebs on Security is highly recommended.

The debate between synthetic and organic alkaloids revolves around purity, the predictability of effects, and therapeutic value. Synthetics, while offering a controlled dosage and easier accessibility, lack the complex array of compounds found in natural sources, which may contribute to the overall therapeutic experience. This discussion underscores the need for more research into both synthetic and natural psychedelics to understand their full potential and implications for mental health treatments. Amidst the evolving landscape of psychedelic research and use, the role of unregulated head shops has emerged as a significant concern. These establishments, often operating in legal gray areas, have become conduits for the distribution of new substances like 4-AcO-DET, leveraging the compound’s “non-detectable” status to bypass existing regulatory frameworks. This situation not only complicates efforts to ensure the safety and quality of psychedelic substances but also raises alarms about the accessibility of these potent compounds to minors. Without stringent oversight and standardized testing protocols, unregulated head shops can inadvertently contribute to the misuse of psychedelics, underscoring the urgent need for comprehensive policies that address the sale and distribution of novel psychoactive substances while protecting public health and safety.

The shift from 4-AcO-DMT to 4-AcO-DET in the production of psychedelic substances can also be attributed to operational risks encountered by manufacturers. Specifically, the crackdown on the precursor chemicals required for synthesizing 4-AcO-DMT, marked by significant legal actions including busts, has made these precursors “flagged” and monitored more closely by authorities. This heightened scrutiny led those involved in the large-scale production of 4-AcO-DMT to halt their operations, seeking alternative compounds that could circumvent these new challenges.

In this context, 4-AcO-DET has become the compound of choice for several reasons. It shares a very similar psychoactive profile with 4-AcO-DMT, offering comparable effects and dosages, which makes it an attractive alternative for both producers and users seeking similar experiences. However, a key advantage of 4-AcO-DET lies in its current status regarding drug testing methodologies, particularly High-Performance Liquid Chromatography (HPLC). Due to the lack of established standards for 4-AcO-DET, it does not show conclusive results on HPLC screenings, making it more difficult to detect and therefore more appealing for clandestine production. This transition reflects a strategic shift within the psychedelic substance market, driven by the desire to continue operations amidst increasing regulatory pressures and the evolving landscape of drug enforcement and detection.

4-AcO-DET - Wikipedia

Understanding Non-Detectable Psilocybin Analogues:Non-detectable psilocybin analogues, like 4-AcO-DET, are synthetic compounds that mimic the effects of psilocybin, the psychoactive ingredient in certain species of mushrooms. 4-AcO-DET stands for 4-Acetoxy-N,N-diethyltryptamine, a molecule closely related to psilocybin and psilocin (the compound into which psilocybin is converted in the body). These analogues are considered “non-detectable” due to the current limitations in drug testing technology, which often do not include specific standards for identifying these newer synthetic compounds.

The Chemistry and Effects of 4-AcO-DET: 4-AcO-DET features a chemical structure with an acetoxy group attached to the indole ring of the tryptamine backbone, similar to psilocin. This structural similarity suggests that 4-AcO-DET acts as a prodrug to ethocin, thereby producing effects similar to those of psilocybin. Users of 4-AcO-DET report experiences of euphoria, visual hallucinations, altered perception of time and space, and profound changes in thought and emotion, which closely parallel the psychedelic experience induced by psilocybin mushrooms.

Shift in Production from 4-AcO-DMT to 4-AcO-DET:For those recently familiarizing themselves with the psychedelic compound 4-AcO-DMT, it’s noteworthy that its production has significantly dwindled. This change came about as the precursors for 4-AcO-DMT were flagged following a high-profile bust, causing producers to pivot towards synthesizing 4-AcO-DET instead. 4-AcO-DET, while offering the same psychedelic effects and dosages as 4-AcO-DMT, remains challenging to detect using High-Performance Liquid Chromatography (HPLC) due to the lack of a standardized testing method. However, users should note that 4-AcO-DET has a slightly more bitter taste, necessitating adjustments in formulations, such as the addition of bitter blockers in edibles.

Challenges and Considerations: The classification of 4-AcO-DET and similar compounds as “non-detectable” raises important considerations regarding safety, legality, and research. The absence of standardized tests for these substances complicates efforts to understand their full pharmacological profile, potential risks, and therapeutic benefits. Moreover, the legal status of such compounds can vary significantly across different jurisdictions, often lagging behind the pace of new substance development and discovery.

The therapeutic potential of these analogues, mirroring that of psilocybin, opens up new avenues for research into mental health treatments. However, the novelty and variability of these compounds necessitate a cautious approach, emphasizing the importance of controlled studies to elucidate their efficacy, safety, and mechanisms of action.

The exploration of non-detectable psilocybin analogues like 4-AcO-DET represents a fascinating frontier in psychedelic research, offering both challenges and opportunities. While these substances promise to expand our understanding of psychedelic pharmacology and its potential applications, they also underscore the need for advancements in detection methodologies, regulatory frameworks, and scientific research. As we continue to investigate these compounds, a balanced approach that considers both their potential benefits and risks will be crucial in harnessing their full potential.


  1. 4-AcO-DMT by Albert Hofmann And Franz Troxler
  2. Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse brain
  3. Mushroom Extract Outperforms Synthetic Psilocybin in Psychiatric Therapy
  4. Incognito Darknet Market Mass-Extorts Buyers, Sellers

About Rev

“Rev” Hooman (Rev as in revelation) is the Founder of Entheology Project, a 508(c)(1)(a) Non-Profit Entheogenic Support Organization. We wrote MushGPT, a free entheogenic AI chatbot that raises entheo Seeker awareness. Please check out our projects and let us know how we can facilitate you! 🍄❤️✌️

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